Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research.
Identifieur interne : 000522 ( Main/Exploration ); précédent : 000521; suivant : 000523Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research.
Auteurs : Adam T. Hill [Éthiopie] ; Charles S. Haworth [Royaume-Uni] ; Stefano Aliberti [Italie] ; Alan Barker [États-Unis] ; Francesco Blasi [Italie] ; Wim Boersma [Pays-Bas] ; James D. Chalmers [Royaume-Uni] ; Anthony De Soyza [Royaume-Uni] ; Katerina Dimakou [Grèce] ; J Stuart Elborn [Royaume-Uni] ; Charles Feldman [Afrique du Sud] ; Patrick Flume [États-Unis] ; Pieter C. Goeminne [Belgique] ; Michael R. Loebinger [Royaume-Uni] ; Rosario Menendez [Espagne] ; Lucy Morgan [Australie] ; Marlene Murris [France] ; Eva Polverino [Espagne] ; Alexandra Quittner [États-Unis] ; Felix C. Ringshausen [Allemagne] ; Gregory Tino [États-Unis] ; Antoni Torres [Espagne] ; Montserrat Vendrell [Espagne] ; Tobias Welte [Allemagne] ; Rob Wilson [Royaume-Uni] ; Conroy Wong [Nouvelle-Zélande] ; Anne O'Donnell [États-Unis] ; Timothy Aksamit [États-Unis]Source :
- The European respiratory journal [ 1399-3003 ] ; 2017.
Abstract
There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required.The working group proposes the use of this consensus-based definition for bronchiectasis exacerbation in future clinical research involving adults with bronchiectasis.
DOI: 10.1183/13993003.00051-2017
PubMed: 28596426
Affiliations:
- Afrique du Sud, Allemagne, Australie, Belgique, Espagne, France, Grèce, Italie, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, États-Unis, Éthiopie
- Angleterre, Attique (région), Basse-Saxe, Caroline du Sud, Catalogne, District de Columbia, Floride, Gauteng, Grand Londres, Lombardie, Midi-Pyrénées, Minnesota, Occitanie (région administrative), Oregon, Pennsylvanie, Écosse
- Athènes, Barcelone, Hanovre, Johannesbourg, Londres, Milan, Toulouse, Édimbourg
- Université d'Édimbourg, Université du Witwatersrand
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Ringshausen</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept of Respiratory Medicine, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Tino, Gregory" sort="Tino, Gregory" uniqKey="Tino G" first="Gregory" last="Tino">Gregory Tino</name><affiliation wicri:level="2"><nlm:affiliation>Dept of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Torres, Antoni" sort="Torres, Antoni" uniqKey="Torres A" first="Antoni" last="Torres">Antoni Torres</name><affiliation wicri:level="3"><nlm:affiliation>Fundaciò Clìnic, IDIBAPS, CIBERES, Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundaciò Clìnic, IDIBAPS, CIBERES, Hospital Clinic de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vendrell, Montserrat" sort="Vendrell, Montserrat" uniqKey="Vendrell M" first="Montserrat" last="Vendrell">Montserrat Vendrell</name><affiliation wicri:level="1"><nlm:affiliation>Bronchiectasis Group, IDIBGI, CIBERES, Dr Trueta University Hospital, Girona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Bronchiectasis Group, IDIBGI, CIBERES, Dr Trueta University Hospital, Girona</wicri:regionArea><wicri:noRegion>Girona</wicri:noRegion></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept of Respiratory Medicine, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Wilson, Rob" sort="Wilson, Rob" uniqKey="Wilson R" first="Rob" last="Wilson">Rob Wilson</name><affiliation wicri:level="3"><nlm:affiliation>Host Defence Unit, Royal Brompton Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Host Defence Unit, Royal Brompton Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wong, Conroy" sort="Wong, Conroy" uniqKey="Wong C" first="Conroy" last="Wong">Conroy Wong</name><affiliation wicri:level="1"><nlm:affiliation>Dept of Respiratory Medicine, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Dept of Respiratory Medicine, Middlemore Hospital, Counties Manukau District Health Board, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, Anne" sort="O Donnell, Anne" uniqKey="O Donnell A" first="Anne" last="O'Donnell">Anne O'Donnell</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary, Critical Care and Sleep Medicine, Georgetown University Medical Center, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Critical Care and Sleep Medicine, Georgetown University Medical Center, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Aksamit, Timothy" sort="Aksamit, Timothy" uniqKey="Aksamit T" first="Timothy" last="Aksamit">Timothy Aksamit</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic College of Medicine, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date 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with bronchiectasis: a consensus definition for clinical research.</title><author><name sortKey="Hill, Adam T" sort="Hill, Adam T" uniqKey="Hill A" first="Adam T" last="Hill">Adam T. Hill</name><affiliation wicri:level="4"><nlm:affiliation>Royal Infirmary and University of Edinburgh, Edinburgh, UK adam.hill318@nhs.net.</nlm:affiliation><country wicri:rule="url">Éthiopie</country><wicri:regionArea>Royal Infirmary and University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Haworth, Charles S" sort="Haworth, Charles S" uniqKey="Haworth C" first="Charles S" last="Haworth">Charles S. Haworth</name><affiliation wicri:level="1"><nlm:affiliation>Cambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Centre for Lung Infection, Papworth Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Aliberti, Stefano" sort="Aliberti, Stefano" uniqKey="Aliberti S" first="Stefano" last="Aliberti">Stefano Aliberti</name><affiliation wicri:level="3"><nlm:affiliation>Respiratory Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dept of Pathophysiology and Transplantation, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Respiratory Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dept of Pathophysiology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Barker, Alan" sort="Barker, Alan" uniqKey="Barker A" first="Alan" last="Barker">Alan Barker</name><affiliation wicri:level="2"><nlm:affiliation>Dept of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Blasi, Francesco" sort="Blasi, Francesco" uniqKey="Blasi F" first="Francesco" last="Blasi">Francesco Blasi</name><affiliation wicri:level="3"><nlm:affiliation>Respiratory Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dept of Pathophysiology and Transplantation, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Respiratory Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dept of Pathophysiology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Boersma, Wim" sort="Boersma, Wim" uniqKey="Boersma W" first="Wim" last="Boersma">Wim Boersma</name><affiliation wicri:level="1"><nlm:affiliation>Dept of Pulmonary Diseases, Medical Centre Alkmaar, Alkmaar, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept of Pulmonary Diseases, Medical Centre Alkmaar, Alkmaar</wicri:regionArea><wicri:noRegion>Alkmaar</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, James D" sort="Chalmers, James D" uniqKey="Chalmers J" first="James D" last="Chalmers">James D. Chalmers</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>College of Medicine University of Dundee, Ninewells Hospital and Medical School, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="De Soyza, Anthony" sort="De Soyza, Anthony" uniqKey="De Soyza A" first="Anthony" last="De Soyza">Anthony De Soyza</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University and Bronchiectasis Service Freeman Hospital, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University and Bronchiectasis Service Freeman Hospital, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Dimakou, Katerina" sort="Dimakou, Katerina" uniqKey="Dimakou K" first="Katerina" last="Dimakou">Katerina Dimakou</name><affiliation wicri:level="3"><nlm:affiliation>5th Pulmonary Dept, "Sotiria" Chest Hospital, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>5th Pulmonary Dept, "Sotiria" Chest Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Elborn, J Stuart" sort="Elborn, J Stuart" uniqKey="Elborn J" first="J Stuart" last="Elborn">J Stuart Elborn</name><affiliation wicri:level="3"><nlm:affiliation>Imperial College and Royal Brompton Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College and Royal Brompton Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Feldman, Charles" sort="Feldman, Charles" uniqKey="Feldman C" first="Charles" last="Feldman">Charles Feldman</name><affiliation wicri:level="4"><nlm:affiliation>Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Flume, Patrick" sort="Flume, Patrick" uniqKey="Flume P" first="Patrick" last="Flume">Patrick Flume</name><affiliation wicri:level="2"><nlm:affiliation>Dept of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Goeminne, Pieter C" sort="Goeminne, Pieter C" uniqKey="Goeminne P" first="Pieter C" last="Goeminne">Pieter C. Goeminne</name><affiliation wicri:level="1"><nlm:affiliation>Dept of Respiratory Medicine, AZ Nikolaas, Sint-Niklaas, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Dept of Respiratory Medicine, AZ Nikolaas, Sint-Niklaas</wicri:regionArea><wicri:noRegion>Sint-Niklaas</wicri:noRegion></affiliation></author><author><name sortKey="Loebinger, Michael R" sort="Loebinger, Michael R" uniqKey="Loebinger M" first="Michael R" last="Loebinger">Michael R. Loebinger</name><affiliation wicri:level="3"><nlm:affiliation>Host Defence Unit, Royal Brompton Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Host Defence Unit, Royal Brompton Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Menendez, Rosario" sort="Menendez, Rosario" uniqKey="Menendez R" first="Rosario" last="Menendez">Rosario Menendez</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Service, Universitary and Polytechnic Hospital La Fe, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pneumology Service, Universitary and Polytechnic Hospital La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Morgan, Lucy" sort="Morgan, Lucy" uniqKey="Morgan L" first="Lucy" last="Morgan">Lucy Morgan</name><affiliation wicri:level="1"><nlm:affiliation>Concord Hospital, Concord, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Concord Hospital, Concord</wicri:regionArea><wicri:noRegion>Concord</wicri:noRegion></affiliation></author><author><name sortKey="Murris, Marlene" sort="Murris, Marlene" uniqKey="Murris M" first="Marlene" last="Murris">Marlene Murris</name><affiliation wicri:level="3"><nlm:affiliation>Service de Pneumologie, Hopital Larrey, CHU de Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Pneumologie, Hopital Larrey, CHU de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Polverino, Eva" sort="Polverino, Eva" uniqKey="Polverino E" first="Eva" last="Polverino">Eva Polverino</name><affiliation wicri:level="3"><nlm:affiliation>Fundaciò Clìnic, IDIBAPS, CIBERES, Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundaciò Clìnic, IDIBAPS, CIBERES, Hospital Clinic de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Quittner, Alexandra" sort="Quittner, Alexandra" uniqKey="Quittner A" first="Alexandra" last="Quittner">Alexandra Quittner</name><affiliation wicri:level="2"><nlm:affiliation>Behavioral Health Systems Research, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Behavioral Health Systems Research, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ringshausen, Felix C" sort="Ringshausen, Felix C" uniqKey="Ringshausen F" first="Felix C" last="Ringshausen">Felix C. Ringshausen</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept of Respiratory Medicine, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Tino, Gregory" sort="Tino, Gregory" uniqKey="Tino G" first="Gregory" last="Tino">Gregory Tino</name><affiliation wicri:level="2"><nlm:affiliation>Dept of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Torres, Antoni" sort="Torres, Antoni" uniqKey="Torres A" first="Antoni" last="Torres">Antoni Torres</name><affiliation wicri:level="3"><nlm:affiliation>Fundaciò Clìnic, IDIBAPS, CIBERES, Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundaciò Clìnic, IDIBAPS, CIBERES, Hospital Clinic de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vendrell, Montserrat" sort="Vendrell, Montserrat" uniqKey="Vendrell M" first="Montserrat" last="Vendrell">Montserrat Vendrell</name><affiliation wicri:level="1"><nlm:affiliation>Bronchiectasis Group, IDIBGI, CIBERES, Dr Trueta University Hospital, Girona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Bronchiectasis Group, IDIBGI, CIBERES, Dr Trueta University Hospital, Girona</wicri:regionArea><wicri:noRegion>Girona</wicri:noRegion></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept of Respiratory Medicine, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Wilson, Rob" sort="Wilson, Rob" uniqKey="Wilson R" first="Rob" last="Wilson">Rob Wilson</name><affiliation wicri:level="3"><nlm:affiliation>Host Defence Unit, Royal Brompton Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Host Defence Unit, Royal Brompton Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wong, Conroy" sort="Wong, Conroy" uniqKey="Wong C" first="Conroy" last="Wong">Conroy Wong</name><affiliation wicri:level="1"><nlm:affiliation>Dept of Respiratory Medicine, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Dept of Respiratory Medicine, Middlemore Hospital, Counties Manukau District Health Board, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, Anne" sort="O Donnell, Anne" uniqKey="O Donnell A" first="Anne" last="O'Donnell">Anne O'Donnell</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary, Critical Care and Sleep Medicine, Georgetown University Medical Center, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Critical Care and Sleep Medicine, Georgetown University Medical Center, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Aksamit, Timothy" sort="Aksamit, Timothy" uniqKey="Aksamit T" first="Timothy" last="Aksamit">Timothy Aksamit</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic College of Medicine, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j">The European respiratory journal</title><idno type="eISSN">1399-3003</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required.The working group proposes the use of this consensus-based definition for bronchiectasis exacerbation in future clinical research involving adults with bronchiectasis.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li><li>Éthiopie</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Basse-Saxe</li><li>Caroline du Sud</li><li>Catalogne</li><li>District de Columbia</li><li>Floride</li><li>Gauteng</li><li>Grand Londres</li><li>Lombardie</li><li>Midi-Pyrénées</li><li>Minnesota</li><li>Occitanie (région administrative)</li><li>Oregon</li><li>Pennsylvanie</li><li>Écosse</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Hanovre</li><li>Johannesbourg</li><li>Londres</li><li>Milan</li><li>Toulouse</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université du Witwatersrand</li></orgName></list><tree><country name="Éthiopie"><region name="Écosse"><name sortKey="Hill, Adam T" sort="Hill, Adam T" uniqKey="Hill A" first="Adam T" last="Hill">Adam T. Hill</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Haworth, Charles S" sort="Haworth, Charles S" uniqKey="Haworth C" first="Charles S" last="Haworth">Charles S. Haworth</name></noRegion><name sortKey="Chalmers, James D" sort="Chalmers, James D" uniqKey="Chalmers J" first="James D" last="Chalmers">James D. Chalmers</name><name sortKey="De Soyza, Anthony" sort="De Soyza, Anthony" uniqKey="De Soyza A" first="Anthony" last="De Soyza">Anthony De Soyza</name><name sortKey="Elborn, J Stuart" sort="Elborn, J Stuart" uniqKey="Elborn J" first="J Stuart" last="Elborn">J Stuart Elborn</name><name sortKey="Loebinger, Michael R" sort="Loebinger, Michael R" uniqKey="Loebinger M" first="Michael R" last="Loebinger">Michael R. Loebinger</name><name sortKey="Wilson, Rob" sort="Wilson, Rob" uniqKey="Wilson R" first="Rob" last="Wilson">Rob Wilson</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Aliberti, Stefano" sort="Aliberti, Stefano" uniqKey="Aliberti S" first="Stefano" last="Aliberti">Stefano Aliberti</name></region><name sortKey="Blasi, Francesco" sort="Blasi, Francesco" uniqKey="Blasi F" first="Francesco" last="Blasi">Francesco Blasi</name></country><country name="États-Unis"><region name="Oregon"><name sortKey="Barker, Alan" sort="Barker, Alan" uniqKey="Barker A" first="Alan" last="Barker">Alan Barker</name></region><name sortKey="Aksamit, Timothy" sort="Aksamit, Timothy" uniqKey="Aksamit T" first="Timothy" last="Aksamit">Timothy Aksamit</name><name sortKey="Flume, Patrick" sort="Flume, Patrick" uniqKey="Flume P" first="Patrick" last="Flume">Patrick Flume</name><name sortKey="O Donnell, Anne" sort="O Donnell, Anne" uniqKey="O Donnell A" first="Anne" last="O'Donnell">Anne O'Donnell</name><name sortKey="Quittner, Alexandra" sort="Quittner, Alexandra" uniqKey="Quittner A" first="Alexandra" last="Quittner">Alexandra Quittner</name><name sortKey="Tino, Gregory" sort="Tino, Gregory" uniqKey="Tino G" first="Gregory" last="Tino">Gregory Tino</name></country><country name="Pays-Bas"><noRegion><name sortKey="Boersma, Wim" sort="Boersma, Wim" uniqKey="Boersma W" first="Wim" last="Boersma">Wim Boersma</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Dimakou, Katerina" sort="Dimakou, Katerina" uniqKey="Dimakou K" first="Katerina" last="Dimakou">Katerina Dimakou</name></region></country><country name="Afrique du Sud"><region name="Gauteng"><name sortKey="Feldman, Charles" sort="Feldman, Charles" uniqKey="Feldman C" first="Charles" last="Feldman">Charles Feldman</name></region></country><country name="Belgique"><noRegion><name sortKey="Goeminne, Pieter C" sort="Goeminne, Pieter C" uniqKey="Goeminne P" first="Pieter C" last="Goeminne">Pieter C. Goeminne</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Menendez, Rosario" sort="Menendez, Rosario" uniqKey="Menendez R" first="Rosario" last="Menendez">Rosario Menendez</name></noRegion><name sortKey="Polverino, Eva" sort="Polverino, Eva" uniqKey="Polverino E" first="Eva" last="Polverino">Eva Polverino</name><name sortKey="Torres, Antoni" sort="Torres, Antoni" uniqKey="Torres A" first="Antoni" last="Torres">Antoni Torres</name><name sortKey="Vendrell, Montserrat" sort="Vendrell, Montserrat" uniqKey="Vendrell M" first="Montserrat" last="Vendrell">Montserrat Vendrell</name></country><country name="Australie"><noRegion><name sortKey="Morgan, Lucy" sort="Morgan, Lucy" uniqKey="Morgan L" first="Lucy" last="Morgan">Lucy Morgan</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Murris, Marlene" sort="Murris, Marlene" uniqKey="Murris M" first="Marlene" last="Murris">Marlene Murris</name></region></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Ringshausen, Felix C" sort="Ringshausen, Felix C" uniqKey="Ringshausen F" first="Felix C" last="Ringshausen">Felix C. Ringshausen</name></region><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Wong, Conroy" sort="Wong, Conroy" uniqKey="Wong C" first="Conroy" last="Wong">Conroy Wong</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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